Table 3.
Potential Risk Factors of Poor OS for HCC Patients
| Variables | No. of Cases | Univariate Analysis | Multivariate Analysis | ||
|---|---|---|---|---|---|
| Hazard Ratio (95% CI) | P | Hazard Ratio (95% CI) | P | ||
| Modalities (TACE-MWA/TACE alone) | 91/140 | 2.980 (1.899–4.679) | <0.001 | 2.751 (1.678–4.510) | <0.001 |
| Sex (male/female) | 205/26 | 0.763 (0.398–1.459) | 0.413 | 1.160 (0.571–2.357) | 0.681 |
| Age (≤55/>55 years) | 115/116 | 0.808 (0.559–1.167) | 0.255 | 1.095 (0.731–1.641) | 0.659 |
| Etiologies of cirrhosis (none/HBV/HCV/Alcohol/Cryptogenic) | 27/188/7/3/6 | 0.963 (0.718–1.291) | 0.800 | 1.028 (0.756–1.397) | 0.862 |
| Platelet count (≤50/>50 ×109) | 11/220 | 1.127 (0.459–2.766) | 0.794 | 1.081 (0.409–2.856) | 0.875 |
| Albumin (≤35/>35 g/L) | 62/169 | 0.972 (0.650–1.455) | 0.891 | 0.912 (0.604–1.376) | 0.660 |
| Total bilirubin (≤17.1/>17.1 umol/L) | 143/88 | 1.059 (0.728–1.541) | 0.763 | 1.134 (0.764–1.682) | 0.532 |
| AFP level (≤400/>400 ng/mL) | 142/89 | 1.476 (1.020–2.135) | 0.039 | 1.456 (0.982–2.160) | 0.062 |
| Tumor distribution (unilobar/bilobar) | 150/81 | 1.476 (1.018–2.139) | 0.040 | 1.404 (0.942–2.091) | 0.095 |
| Size of the largest tumor (≤50/>50 mm) | 49/182 | 1.888 (1.127–3.162) | 0.016 | 1.984 (1.073–3.666) | 0.029 |
| Number of tumors (single/multiple) | 113/118 | 1.190 (0.823–1.719) | 0.356 | 1.412 (0.906–2.203) | 0.128 |
Abbreviations: OS, overall survival; HCC, hepatocellular carcinoma; TACE, transarterial chemoembolization; MWA, microwave ablation; AFP, Alpha fetoprotein.