FIG 1.

Timeline of ESX-1 studies performed in M. marinum (7–12, 26, 27, 31, 44, 47, 48, 63, 73–78, 85, 87, 92, 103, 104, 113, 117, 118, 127, 128, 134, 141, 148, 151, 154, 166, 168, 200–206). The timeline shows major contributions from M. marinum (M. mar) studies from ∼2004 to 2020. The four lines indicate major aspects of the ESX-1 field. The list of foundational studies performed on M. tuberculosis and other slow-growing mycobacterial species as well as the highlighted M. marinum studies are not comprehensive. IFN, interferon; CT, C terminus.