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. 2021 Nov 5;25:101417. doi: 10.1016/j.genrep.2021.101417

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Fig. 4 — Likely mechanisms of suppression of the type 1 interferon response during SARS-CoV-2 infection. Structural and nonstructural proteins of virus or double membrane vesicles (DMVs) can shield PAMPs from immune sensors. Structural and nonstructural proteins also inactivate immune sensors or components of downstream type I IFN signaling. Abbreviations: DMV, double membrane vesicle; ISG, IFN-stimulated gene; MDA5, melanoma differentiation-associated protein 5.