Amsterdam Metoprolol Trial 1983.

Study characteristics
Methods	Randomised clinical trial at a single site in Sweden. Duration not mentioned
Participants	584 participants younger than 70 years of age, NYHA Class I/II, and 3 to 5 weeks after MI were included in the trial Male:female = not mentioned Mean age = not mentioned Exclusion criteria: not mentioned
Interventions	Experimental group: metoprolol (100 mg b.i.d.) (n = 291) Control group: placebo (n = 293) Co‐intervention: not mentioned Excluded medication: not mentioned
Outcomes	Outcomes: mortality, non‐fatal myocardial reinfarction, arrhythmias Time point reported: 24 months
Notes	Email was not found The original study could not be found. Therefore, we used data from Yusuf 1985 (study referred to as 'Manger Cats'), which Bangalore 2014 has referred to as well MACE was calculated and was reported as a composite of 'non‐fatal reinfarction + sudden death (presumably arrhythmic or cardiac rupture)' Funding not described
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Not described
Allocation concealment (selection bias)	Unclear risk	Not described
Blinding of participants and personnel (performance bias) All outcomes	Unclear risk	Not described
Blinding of outcome assessment (detection bias) All outcomes	Unclear risk	Not described
Incomplete outcome data (attrition bias) All outcomes	Unclear risk	Not described
Selective reporting (reporting bias)	Unclear risk	No protocol could be found; however mortality was reported
Other bias	Low risk	No other biases were found