Fig 2. Linking context-dependent chromatin accessibility to candidate genes.

(A-C) Schematic of three approaches to link peaks to genes. Day 0 (light blue) and day 14 (dark blue) context-dependent peaks are represented. (A) Context-dependent peaks that overlap elements connected to gene promoters using adipocyte promoter capture Hi-C (orange). (B) Context-dependent peaks that overlap adipose gene eQTL variants (r²>.8 with lead, red). (C) Context-dependent peaks linked to a gene through Hi-C or eQTL for which the linked gene was also differentially expressed between any timepoints (green). (D) Histogram of distances from edges of peaks to the transcription start site of a linked gene within 1.2 Mb. Values in S12 Table. (E) Numbers of context-dependent peaks linked to genes by each method and by two or more methods. Values summarize full results in S12 Table.