Fig 4.

Comparisons of simulation results for each gene using the MC2020 model, with synonymous substitutions only, applied to each of the four ancestral sequences, with the extant sequence CAI values (blue). The ancestral sequences that yielded the highest and lowest simulation lines, determined by the CAI value of the ancestral sequences, are indicated and colored red and green respectively. For each gene the two plots are for the minimum (A) and maximum (B) number of mutations estimated from one of the reconstructed ancestral sequences (see text).