Table 2. Univariable and multivariable analysis of factors associated with SARS-CoV-2 vaccine uptake.
| Variable | n vaccinated/N total (%) | OR (95% CI) | p-Value | aOR (95% CI) | p-Value |
|---|---|---|---|---|---|
| Age (years) | |||||
| ≤30 | 2,290/4,432 (51.7) | 0.45 (0.41–0.49) | <0.001 | 0.48 (0.44–0.53) | <0.001 |
| 31–40 | 2,681/4,656 (57.6) | 0.57 (0.52–0.62) | <0.001 | 0.64 (0.58–0.70) | <0.001 |
| 41–50 | 3,037/4,312 (70.4) | Reference | <0.001 | Reference | — |
| 51–60 | 3,126/4,101 (76.2) | 1.35 (1.22–1.48) | <0.001 | 1.19 (1.07–1.31) | 0.001 |
| ≥61 | 1,144/1,543 (74.1) | 1.20 (1.06–1.37) | <0.001 | 1.18 (1.03–1.36) | 0.02 |
| Sex | |||||
| Female | 9,296/14,395 (64.6) | Reference | — | Reference | — |
| Male | 2,982/4,649 (64.1) | 0.98 (0.92–1.05) | 0.59 | 1.24 (1.15–1.35) | <0.001 |
| Ethnicity | |||||
| White | 8,147/11,485 (70.9) | Reference | — | Reference | — |
| South Asian | 2,843/4,863 (58.5) | 0.58 (0.54–0.62) | <0.001 | 0.67 (0.62–0.72) | <0.001 |
| Black | 499/1,357 (36.8) | 0.24 (0.21–0.27) | <0.001 | 0.30 (0.26–0.34) | <0.001 |
| Other | 609/1,038 (58.7) | 0.58 (0.51–0.66) | <0.001 | 0.70 (0.61–0.81) | <0.001 |
| Not stated | 180/301 (59.8) | 0.61 (0.48–0.77) | <0.001 | 0.64 (0.50–0.82) | <0.001 |
| IMD quintile | |||||
| 5 (least deprived) | 3,274/4,597 (71.2) | Reference | — | Reference | — |
| 4 | 2,745/4,010 (68.5) | 0.87 (0.80–0.96) | 0.005 | 0.91 (0.82–1.00) | 0.046 |
| 3 | 2,127/3,302 (64.4) | 0.73 (0.67–0.81) | <0.001 | 0.84 (0.75–0.93) | 0.001 |
| 2 | 2,403/4,085 (58.8) | 0.58 (0.53–0.63) | <0.001 | 0.80 (0.72–0.87) | <0.001 |
| 1 (most deprived) | 1,688/2,940 (57.4) | 0.55 (0.50–0.60) | <0.001 | 0.77 (0.69–0.86) | <0.001 |
| Occupation | |||||
| Doctor | 1,721/3,001 (57.4) | Reference | — | Reference | — |
| Nurse/midwife/HCA | 4,886/7,815 (62.5) | 1.24 (1.14–1.35) | <0.001 | 1.03 (0.93–1.15) | 0.52 |
| Allied health professional | 953/1,380 (69.1) | 1.66 (1.45–1.90) | <0.001 | 1.40 (1.20–1.62) | <0.001 |
| Administrative/executive | 2,537/3,465 (73.2) | 2.03 (1.83–2.26) | <0.001 | 1.48 (1.32–1.66) | <0.001 |
| Healthcare scientist | 634/871 (72.8) | 1.99 (1.69–2.35) | <0.001 | 1.69 (1.41–2.02) | <0.001 |
| Estates/facilities | 1,399/2,306 (60.7) | 1.15 (1.03–1.28) | 0.015 | 0.93 (0.82–1.05) | 0.27 |
| Other | 148/206 (71.8) | 1.90 (1.39–2.59) | <0.001 | 1.45 (1.04–2.01) | 0.03 |
| Previous SARS-CoV-2 serology | |||||
| Negative | 7,582/10,314 (73.5) | Reference | — | Reference | — |
| Never tested | 3,800/7,456 (51.0) | 0.37 (0.35–0.40) | <0.001 | 0.46 (0.43–0.50) | <0.001 |
| Positive | 896/1,274 (70.3) | 0.85 (0.75–0.97) | 0.02 | 1.01 (0.88–1.15) | 0.94 |
| Previous SARS-CoV-2 PCR | |||||
| Negative | 2,311/3,072 (75.2) | Reference | — | Reference | — |
| Never tested | 9,426/15,136 (62.3) | 0.54 (0.50–0.59) | <0.001 | 0.70 (0.64–0.77) | <0.001 |
| Positive | 541/836 (64.7) | 0.60 (0.51–0.71) | <0.001 | 0.71 (0.60–0.85) | <0.001 |
| Previous COVID-19-related work absence | |||||
| No absence | 7,846/12,489 (62.8) | Reference | — | Reference | — |
| Symptomatic | 2,477/3,698 (67.0) | 1.20 (1.11–1.30) | <0.001 | 1.06 (0.97–1.16) | 0.17 |
| Household or test and trace contact | 1,931/2,727 (70.8) | 1.44 (1.31–1.57) | <0.001 | 1.29 (1.17–1.42) | <0.001 |
| Pregnant | 24/130 (18.5) | 0.13 (0.09–0.20) | <0.001 | 0.21 (0.14–0.34) | <0.001 |
aOR, adjusted odds ratio (adjusted for all variables in the table); COVID-19, coronavirus disease 2019; HCA, healthcare assistant; IMD, Index of Multiple Deprivation; OR, odds ratio; PCR, polymerase chain reaction; SARS-CoV-2, severe acute respiratory syndrome coronavirus 2.