Fig. 2.

A method to calculate a normalized vascular damage severity (VDS) score and an Alzheimer's disease severity (ADS) score based on vascular and Alzheimer's factors is presented. We illustrate this general concept based on two vascular factors, consisting of white matter hyperintensity (WMH) volume and the peak width skeletonized mean diffusivity (PSMD) measured from the diffusion image, and two Alzheimer's factors, consisting of Aβ Ratio and pTau. These two factors are then used to generate a VDS score and the ADS score in the range (0,1), based on the one class clustering method.