Table 2.

Apparent First-Order Rate Constant k_obs and Permeability Coefficient P_app of Rifampicin Release from Liposomes

entry	liposome composition	types of liposomes	kobs (h−1)a	Papp (nm/h)b	d (nm)c
1	PC/Chol	nonfluid	0.32	3.5	67
2	PC/Chol/Man-DPPE	nonfluid	0.21	2.2	64
3	PC/Chol/G7-DPPE	nonfluid	0.16	2.1	75
4	DPPC/DMPG	fluid	0.47	10.4	133
5	DPPC/DMPG/Man-DPPE	fluid	0.38	8.9	140
6	DPPC/DMPG/G7-DPPE	fluid	0.20	4.8	146

^aDetermined from the slope in Figure 1c,d according to the following equation: $\left[\left(C_0^{\infty }-C_0^0\right)/\left(C_0^{\infty }-C_0^t\right)\right]=k_{\text{obs}}^{\text{t}}$ In (see SI for details).

^bCalculated from the following equation: P_app = k_obs V/A, where V/A = d/6, and d is the hydrodynamic diameter of the liposome (see SI for details).

^cMeasured by DLS.