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. Author manuscript; available in PMC: 2022 Feb 2.
Published in final edited form as: Nat Aging. 2021 Aug 2;1(8):698–714. doi: 10.1038/s43587-021-00089-5

Extended Data Fig. 4: Transcriptome analysis indicates that ABT263 induces multiple favorable changes in plaque pathogenesis.

Extended Data Fig. 4:

a, Heat map of differentially expressed genes upregulated (left) and downregulated (right) by ABT263 treatment in aortic arch plaque (see Fig. 3a for experimental schematic). b, Heat-map of pro-synthetic VSMC phenotype and muscle function genes upregulated with ABT263 treatment. c, Heat-map of anti-calcification changes in gene expression produced by ABT263 treatment among DEGs. d, Heat-map of pro-inflammatory and macrophage polarization DEGs modulated with ABT263 treatment in aortic arch plaque. e, Percentage of Sma+ cells showing TUNEL+ nuclei in fibrous caps (left) and total plaque (right) of indicated groups. Panel e (left and right) were assessed by unpaired, two-tailed Student’s t-test with Welch’s correction. Error bars represent s.e.m. “n” in all cases represents number of individual mice.