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. 2021 May 19;2:655015. doi: 10.3389/fragi.2021.655015

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Copyright © 2021 Stimmell, Xu, Moseley, Cushing, Fernandez, Dang, Santos-Molina, Anzalone, Garcia-Barbon, Rodriguez, Dixon, Wu and Wilber.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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More pTau pathology is predictive of spatial reorientation performance, but only for 6-month female mice. Left. Correlations between pTau raw density for individual brain regions and spatial reorientation performance for the 1.5 and 2.0 s difficulty levels for 6-month female (A) and male (B) mice, 3-month female mice (C), and 12-month male mice (D). Right. Brain region weights (expressed as a proportion) identified by Independent Components Analysis (ICA) for the linear combination that was significantly correlated with spatial reorientation performance for the 1.5 and 2.0 s difficulty levels for 6-month female (A) and male (B) mice, 3-month female mice (C), and 12-month male mice (D). **p < 0.01, ***p < 0.001.