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. 2021 May 19;2:655015. doi: 10.3389/fragi.2021.655015

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Copyright © 2021 Stimmell, Xu, Moseley, Cushing, Fernandez, Dang, Santos-Molina, Anzalone, Garcia-Barbon, Rodriguez, Dixon, Wu and Wilber.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Plaques were absent from most brain regions for all groups except 12-month male 3xTg-AD mice. Top. Representative image of Thioflavin S staining for a 6-month female 3xTg-AD mouse with no plaques. Bottom. Representative image of Thioflavin S staining for a 12-month male 3xTg-AD mouse with plaques (green) in dorsal subiculum (dSub).