Fig. 2. l-Arginine improves the effect of radiation therapy in patients with BM.

(A) Flowchart of clinical trial design with allocation results. (B) Overall responses as number of patients achieving a response category by allocation arm. The P value represents the comparison of complete (CR) plus partial responses (PR) among arms. PD, progressive disease; SD, stable disease. (C) Kaplan-Meier curves of the probability of central nervous system (CNS) progression-free survival in l-arginine and placebo arms. (D) Representative images from an NSCLC patient with BM enrolled in the l-arginine arm of the clinical trial.