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. 2021 Nov 5;7(45):eabg1964. doi: 10.1126/sciadv.abg1964

Fig. 3. Cellular metabolic changes induced by l-arginine administration in TNBC models.

Fig. 3.

(A) Schematic representation of experiments using two TNBC xenograft models. (B) Volcano plots displaying metabolites significantly changed in vehicle- versus l-arginine–treated MDA-MB-231 and MDA-MB-468 xenografts. (C) Boxplot of l-arginine levels in vehicle- versus l-arginine–treated MDA-MB-231 and MDA-MB-468 xenografts. (D) Significantly changed metabolites belonging to the glycolysis pathway and TCA cycle in vehicle- versus l-arginine–treated MDA-MB-231 and MDA-MB-468 xenografts. (E) NAD+ levels in vehicle- versus l-arginine–treated MDA-MB-231 and MDA-MB-468 xenografts. (F) ATP:ADP and (G) ATP:AMP ratios in vehicle- versus l-arginine–treated MDA-MB-231 and MDA-MB-468 xenografts. *Padj < 0.01, **Padj < 0.001, ***Padj < 0.0001, and ****Padj < 0.00001.