Fig. 6. l-Arginine radiosensitizes cancer cells in a NOS2-dependent manner.
(A) Dose response curves of MDA-MB-231, MDA-MB-231-BrM2, MDA-MB-468, and H460 cells exposed to l-arginine for 60 min followed by a dose range of ionizing radiation. (B) Surviving fraction of MDA-MB-231, MDA-MB-231-BrM2, MDA-MB-468, and H460 cells exposed to vehicle or l-arginine for 60 min followed by 2-Gy ionizing radiation with or without the NOS2 inhibitor 1400W. *P < 0.01, **P < 0.001, and ***P < 0.0001.
