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. Author manuscript; available in PMC: 2022 Mar 1.
Published in final edited form as: Genet Epidemiol. 2020 Sep 29;45(2):142–153. doi: 10.1002/gepi.22361

Table 2:

Rejection summaries from the pancreas data: Shows the proportion of genes in the pancreatic islet data with rejected nulls for various hypotheses related to T2D. The TWO-SIGMA model as specified in equation (2) was fit with no zero-inflation variance component (no ZIVC).

Hypothesis Alpha Cells Beta Cells
No ZIVC No ZIVC
Overall Disease Status 0.161 0.111
Overall R.E. Test 0.738 0.724
NB vs. Poisson 0.627 0.555