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. 2021 Nov 2;8(6):ENEURO.0305-21.2021. doi: 10.1523/ENEURO.0305-21.2021

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Copyright © 2021 Nandi et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Figure 4. — Analysis of TST and FST behavior in the CMUS paradigm. Raster plots show the bouts of immobility (black) against time in the TST at (A) day 2 as compared with (B) day 17 of the 21-d-long CMUS paradigm. Bar graphs comparing the behavior in TST at day 2 and day 17 show (C) a significant increase in the % of time spent immobile, (D) a significant decrease in the latency to the first bout of immobility (seconds), and (F) a significant increase in the duration of the longest bout of immobility (seconds). Raster plots reveal the bouts of immobility (shown in black) as a function of time in the FST at (F) day 1 and (G) day 19 of the 21-d-long CMUS paradigm. Bar graphs show (H) a significant increase in the % of time spent immobile, (I) a significant decrease in the latency to the first bout of immobility (seconds), and (J) a significant increase in the duration of the longest bout of immobility (seconds) in the FST paradigm shows; *p < 0.05, two-tailed paired t test; n = 8 mice per group.