Table 2. Complete list of genes that exhibited a consistent and greater than twofold change in expression in the F1 progeny of parents exposed to P. vranovensisor osmotic stress in only species that intergenerationally adapted to stress.

Genes listed for P. vranovensis were identified by comparing genes that change consistently in C. elegans and C. kamaaina, but not C. briggsae. Genes listed for osmotic stress were identified by comparing genes that change consistently in C.elegans, C. briggsae, and C. kamaaina, but not in C. tropicalis. Bold font indicates genes that have already been demonstrated to be involved in C. elegans adaption to these stresses.

Genes that change consistently in F1 progeny of only species that adapt to P. vranovensis	Predicted function
daf-18	Lipid phosphatase, homologous to human PTEN tumor suppressor
gst-38	Glutathione S-transferase
H04M03.3	Predicted to enable oxidoreductase activity.
oops-1	Oocyte partner of SPE-11
F09G8.10	Unknown
glb-1	Globin -related
F57H12.6	Unknown
elo-6	Predicted to enable transferase activity, transferring acyl groups, ortholog of human ELOVL3 and ELOVL6
cpr-5	Predicted to enable cysteine-type peptidase activity
xpo-2	Exportin involved in nuclear export, ortholog of human CSE1L
cysl-1	Cysteine synthase known to be involved in adaptation to P. vranovensis
rhy-1	Regulator of HIF-1 known to be involved in adaptation to P. vranovensis
cdc-25.1	Homolog of human CDC25 phosphatase
imb-1	Importin beta family, ortholog of human KPNB1
VZK882L.2	Unknown
cysl-2	Cysteine synthase known to be involved in adaptation to P. vranovensis
cyk-7	Involved in intercellular bridge organization
Genes that change consistently in F1 progeny of only species that adapt to osmotic stress
T05F1.9	Unknown
grl-21	Unknown, Ground-like domain containing
gpdh-1	Glycerol-3-phosphate dehydrogenase known to be involved in osmotic stress resposne
T22B7.3	Amidinotransferase, ortholog of human DDAH1 and DDAH2