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. 2021 Nov 3;41(44):9177–9191. doi: 10.1523/JNEUROSCI.0885-21.2021

Figure 1.

Figure 1.

Genetic analysis of aromatase expression in mouse embryos. A, Aromatase and τGFP reporter expression are genetically coupled in ArIC/eR26-τGFP mice, providing a fluorescent readout for Cyp19a1 promotor activity. B, Quantification of aromatase neurons during embryonic development (E13.5 vs E16.5 unpaired Student's t tests: p < 0.0001; E16.5 male vs E18.5 female unpaired Student's t tests: p = 0.0127; E16.5 vs E18.5 female unpaired Student's t tests: p = 0.0035). Detailed cell counts for each nucleus are reported in Extended Data Tables 1-1, 1-2, and 1-3. C, D, Reporter expression in the MPOA at E12,5, E13.5, E16.5, and E18.5. E, F, Numerous contacts between aromatase perikarya (unfilled arrowheads) and fibers (filled arrowheads) as shown in the amygdala, MPOA, and dorsomedial nucleus (DM). Scale bars: C, D, 100 µm; E, F, 25 µm. 3V, third ventricle; LV, lateral ventricle, MPN, median preoptic nucleus, MPOA, medial preoptic area.