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. 2021 Nov 3;41(44):9257–9273. doi: 10.1523/JNEUROSCI.0718-21.2021

Figure 1.

Figure 1.

SST interneuron-specific expression of mutant Scn8a is sufficient for susceptibility to audiogenic seizures. A, Audiogenic seizure behavior in mice with cell type-specific expression of R1872W Scn8a mutation. Upon high-intensity acoustic stimulation, Scn8a-EIIaW/+ mice exhibit wild-running (purple) followed by a tonic phase characterized by hindlimb extension (blue), which is followed by collapse of breathing and death (red). Scn8a-SSTW/+ mice exhibit wild-running (purple) but progress to a convulsive clonic phase characterized by repetitive shaking and limb-jerking (orange) followed by recovery (green). B, Propensity of audiogenic seizures in Scn8a-EIIaW/+ (magenta: ∼87%), Scn8a-EMX1W/+ (∼11%), and Scn8a-SSTW/+ (green: ∼82%) mice. *p < 0.01, ***p < 0.001, Fisher's exact test. C-E, Color-coded raster plots for seizure behavior of individual Scn8a-EIIaW/+ (C), Scn8a-EMX1W/+ (D), and Scn8a-SSTW/+ (E) mice.