Table 2.

Membrane and AP properties of WT, Scn8a^D/+, and Scn8a-SST^W/+ SST inhibitory interneurons

	Vm (mV)	AP threshold (mV)	Upstroke velocity (mV/ms)	Downstroke velocity (mV/ms)	AP amplitude (mV)	APD50 (ms)	Input resistance (mΩ)	Rheobase (pA)
WT (n = 52)	−60.2 ± 1.1	−38.5 ± 0.7	286 ± 13	−137 ± 9	72.8 ± 1.6	0.73 ± 0.03	250 ± 16	63 ± 9
Scn8aD/+ (n = 33)	−52.9 ± 1.5***	−38.4 ± 0.8	290 ± 18	−131 ± 7	76.7 ± 1.4	0.69 ± 0.03	298 ± 20	37 ± 7*
Scn8a-SSTW/+ (n = 31)	−54.4 ± 1.6**	−40.8 ± 1.2	231 ± 2.8*	−87 ± 5.7***	73.9 ± 2.0	1.0 ± 0.06***	250 ± 15	37 ± 5*

Data are mean ± SEM.

*p < 0.05,

**p < 0.01,

***p < 0.001, compared with WT using one-way ANOVA followed by Dunnett's multiple comparisons test.