Table 4.

Voltage-gated sodium channel parameters recordings from acutely dissociated WT, Scn8a^D/+, and Scn8a-SST^W/+ SST inhibitory interneurons

	Peak current (pA/pF)	Activation V1/2 (mV) K (mV)		Inactivation V1/2 (mV) K (mV)		Decay tau (ms)
WT (n = 10)	−941 ± 146	−36.4 ± 3.5	4.7 ± 0.5	−63.1 ± 1.9	6.5 ± 0.7	0.83 ± 0.10
Scn8aD/+ (n = 10)	−907 ± 265	−42.3 ± 2.7	3.5 ± 0.3	−65.2 ± 3.8	6.4 ± 0.4	0.70 ± 0.08
Scn8a-SSTW/+ (n = 13)	−902 ± 119	−41.1 ± 2.5	3.8 ± 0.3	−69.2 ± 2.4	6.2 ± 0.5	0.75 ± 0.06

Data are mean ± SEM. All comparisons with WT were nonsignificant using a one-way ANOVA followed by Dunnett's multiple comparisons test.