Table 4.
Multivariate Cox regression analyses of the SII for OS and PFS in NSCLC patients with BM.
| Parameters | OS | PFS | ||
|---|---|---|---|---|
| HR (95% CI) | P value | HR (95% CI) | P value | |
| Age (years) | ||||
| <60 | Reference | 0.010 | ||
| ≥60 | 2.159 (1.205-3.869) | |||
| Smoking history | ||||
| Never smoker | Reference | 0.493 | ||
| Smoker | 1.233 (0.677-2.246) | |||
| KPS | ||||
| 90-100 | Reference | 0.018 | ||
| 70-80 | 1.887 (1.114-3.198) | |||
| Histology type | ||||
| SCC | Reference | 0.153 | ||
| AD | 1.690 (0.822-3.473) | |||
| Primary AJCC stage | ||||
| I | Reference | 0.939 | ||
| II-III | 1.023 (0.576-1.816) | |||
| SII | ||||
| ≤480 | Reference | 0.035 | Reference | 0.004 |
| >480 | 1.938 (1.046-3.589) | 2.224 (1.298-3.810) | ||
| PLR | ||||
| ≤91.5 | Reference | 0.392 | ||
| >91.5 | 1.362 (0.671-2.766) | |||
Abbreviations: BM: brain metastasis; OS: overall survival; PFS: progression-free survival; HR: hazard ratio; CI: confidence interval; KPS: Karnofsky performance status; SCC: squamous cell carcinoma; AD: adenocarcinoma; SII: systemic immune-inflammation index; PLR: platelet-to-lymphocyte ratio.