Table 2.
Mortality prediction AUC of the ACLF-JM vs. the MELD-Na in patients with and without ACLF, at baseline and during follow-up | ||||||||
---|---|---|---|---|---|---|---|---|
ACLF | No ACLF | |||||||
28-day mortality | ACLF-JM | 95% CI | MELD-Na | 95% CI | ACLF-JM | 95% CI | MELD-Na | 95% CI |
Baseline | 0.871 | 0.844-0.898 | 0.788 | 0.754-0.822 | 0.774 | 0.717-0.831 | 0.706 | 0.643-0.769 |
48 hours | 0.871 | 0.844-0.898 | 0.786 | 0.752-0.820 | 0.794 | 0.741-0.847 | 0.728 | 0.668-0.788 |
7 days | 0.862 | 0.833-0.890 | 0.753 | 0.716-0.789 | 0.810 | 0.761-0.859 | 0.740 | 0.684-0.796 |
14 days | 0.840 | 0.803-0.878 | 0.731 | 0.685-0.777 | 0.833 | 0.788-0.879 | 0.748 | 0.694-0.802 |
ACLF | No ACLF | |||||||
90-day mortality | ACLF-JM | 95% CI | MELD-Na | 95% CI | ACLF-JM | 95% CI | MELD-Na | 95% CI |
Baseline | 0.875 | 0.840-0.909 | 0.780 | 0.737-0.823 | 0.836 | 0.807-0.865 | 0.734 | 0.700-0.768 |
48 hours | 0.870 | 0.837-0.903 | 0.777 | 0.735-0.818 | 0.838 | 0.810-0.867 | 0.736 | 0.703-0.770 |
7 days | 0.861 | 0.832-0.891 | 0.755 | 0.717-0.792 | 0.835 | 0.806-0.864 | 0.722 | 0.687-0.757 |
14 days | 0.833 | 0.799-0.868 | 0.719 | 0.677-0.761 | 0.837 | 0.809-0.865 | 0.717 | 0.682-0.752 |
All AUCs differed significantly (p <0.001)
ACLF, acute-on-chronic liver failure; ACLF-JM, acute-on-chronic liver failure joint model; AUC, area under receiver-operating characteristic curve; MELD-Na, model for end-stage liver disease-sodium.