Fig. 1.

Gintonin-enriched fraction (GEF) increases muscle strength, muscle mass, and muscle fiber size in old mice (OM). (A) Weekly body weight measurements and (B) grip strength of mice treated with GEF for 5 weeks. (C) Mass of the gastrocnemius (left) and quadriceps (right) muscles. Muscle mass was normalized to body weight on the final day of the experiment. (D) Histological images of hematoxylin and eosin-stained sections of gastrocnemius (GAS, top) and quadriceps (QUA, bottom) muscles. (E) Quantification of the cross-sectional area (CSA) of muscle fibers. The CSA of each muscle fiber was measured using the Image J program. Statistical significance was decided using one-way ANOVA, followed by Tukey's post-hoc test. Values with different letters are significantly different; p < 0.05 (a > b > c > d).