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. Author manuscript; available in PMC: 2022 Nov 1.
Published in final edited form as: Lancet Respir Med. 2021 May 28;9(11):1241–1254. doi: 10.1016/S2213-2600(21)00079-5

Figure 2: Individual mucin concentrations and COPD severity, and the association between lung function and mucin subtypes and their ratio.

Figure 2:

(A–C) Absolute mean concentrations of MUC5B and MUC5AC, and their ratio, in never-smoker controls, ever-smokers without evidence of COPD by spirometry (at-risk; formerly known as GOLD stage 0), and ever-smokers with mild (GOLD1), moderate (GOLD2), and severe (GOLD3) COPD. (D–F) Mean FEV1 percentage predicted in tercile groups of MUC5AC concentration, MUC5B concentration, and MUC5AC/MUC5B ratio. (G–I) Mean FEV1/FVC in tercile groups of MUC5AC concentration, MUC5B concentration, and MUC5AC/MUC5B ratio. Error bars represent SEM. Sample size for each group is shown in the middle of the bar. COPD=chronic obstructive pulmonary disease. FVC=forced vital capacity. GOLD=Global Initiative for Chronic Obstructive Lung Disease. *p≤0.01. †p≤0.005. ‡p≤0.001. §p≤0.05.