Table 2.

Perturbation sensitivity (feature influence) analysis in emotion circuitry; regions are separated by overlapping vs. unique effects between abuse groups. Within these separations, regions are sorted by descending adjusted R ². R ² and FDR-corrected p -values are for the abuse-perturbed BrainAGE vs. typically-developing-perturbed (chance) BrainAGE comparison. All probability values for the abuse-perturbed BrainAGE vs. true BrainAGE comparison were less than 0.001 and are absent to avoid redundancy.

Effect	Direction	Region	L/R	BA	Power et al. Network	Atlas Label	Adj. R 2	FDR p
Abuse Exposure	Greater BrainAGE	Medial Prefrontal Thalamus	L	-	Subcortical	Tha_8_1	0.087	< 0.001
		Caudal Anterior Cingulate Cortex	R	24	Cingulo-Opercular	CG_7_5	0.076	0.039
		Lateral Prefrontal Thalamus	R	-	Subcortical	Tha_8_8	0.053	0.040
		Caudal Temporal Thalamus	L	-	Subcortical	Tha_8_7	0.049	< 0.001
Unique to Resilient	Greater BrainAGE	Rostral Inferior Parietal Lobule	L	40	Fronto-Parietal	IPL_6_6	0.098	< 0.001
		Premotor Thalamus	L	-	Subcortical	Tha_8_2	0.092	< 0.001
		Dorsal Inferior Parietal Lobule	R	39	Fronto-Parietal	IPL_6_2	0.087	< 0.001
		Dorsolateral Prefrontal Cortex	R	8	Fronto-Parietal	MFG_7_5	0.087	0.006
		Primary Auditory Cortex	L	41	Auditory	STG_6_3	0.042	0.043
		Ventral Caudate Nucleus	L	-	Subcortical	BG_6_1	0.039	0.014
	Reduced BrainAGE	Posterior Parahippocampal Gyrus	R	27	Default-Mode	PhG_6_3	0.098	0.034
		Dorsal Inferior Parietal Lobule	L	39,40	Dorsal Attention	IPL_6_3	0.095	< 0.001
		Dorsal Agranular Insula	R	13	Cingulo-Opercular	INS_6_3	0.083	0.050
		Lateral Orbitofrontal Cortex	R	12/47	Cingulo-Opercular	OrG_6_6	0.080	0.034
		Lateral Opercular Prefrontal Cortex	R	44	Cingulo-Opercular	IFG_6_6	0.079	< 0.001
Unique to Susceptible	Greater BrainAGE	Occipital Thalamus	L	-	Subcortical	Tha_8_6	0.093	< 0.001
		Rostral Temporal Thalamus	L	-	Subcortical	Tha_8_4	0.088	< 0.001
		Dorsal Dysgranular Insula	L	13	Cingulo-Opercular	INS_6_6	0.081	< 0.001
		Opercular Prefrontal Cortex	R	44	Cingulo-Opercular	IFG_6_5	0.051	0.028
	Reduced BrainAGE	Caudal Hippocampus	L	-	Default-Mode	Hipp_2_2	0.088	< 0.001
		Caudal Hippocampus	R	-	Default-Mode	Hipp_2_2	0.087	< 0.001
		Rostral Temporal Thalamus	R	-	Subcortical	Tha_8_4	0.067	< 0.001