TABLE 2.

Urea fold-changes in PDD, AD, and HD.

Region	Fold-change in PDD (this study)	Fold-changes in AD (Xu et al., 2016)	Fold-changes in HD (Patassini et al., 2015)
CB	3.7	4.9	3.6
MCX	4.1	5.0	3.4
PVC	4.3	4.9	3.4
HP	4.2	6.5	3.6
SN	3.9	–	3.5
MTG	4.3	4.7	3.4
MED	4.6	–	–
CG	5.5	5.3	3.5
PONS	3.9	–	–
PUT	–	–	3.7
GP	–	–	3.6
MFG	–	–	3.0
ENT	–	5.6	2.8
Overall	4.3 (3.9–4.6)	5.3 (4.8–5.8)	3.5 (3.2–3.6)

Comparisons of case-control fold-changes in human brain urea levels between PDD, AD, and HD. Case-control differences were significant for every region in every disease. Overall shows mean overall fold-change with ± 95% confidence intervals.