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. 2021 Oct 22;11:760787. doi: 10.3389/fonc.2021.760787

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Copyright © 2021 Charfi, Demeule, Currie, Larocque, Zgheib, Danalache, Ouanouki, Béliveau, Marsolais and Annabi

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of TH1904, Doxorubcin and liposomal Doxorubicin (Doxil) on in vitro vasculogenic mimicry. (A) Representative pictures of 3D capillary-like structures formed at 12 h from ES-2 ovarian cancer cells seeded ontop of Matrigel in the presence of increasing concentrations of TH1904, Doxorubicin, or Doxil. Control (vehicle) was 0.1% DMSO and was kept constant through out the range of cencentrations tested. Scale bar = 1000 μm. (B) 3D capillary-like structures were quantified for total loop numbers as described in the Methods section. Results represent the mean ± SD for n=2 (Doxil, Doxorubicin) and n=4 (TH1904).