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. 2021 Oct 22;9:736509. doi: 10.3389/fchem.2021.736509

TABLE 1.

Chemical structures and clinical indications of FDA and EMA-approved drugs (n = 13) containing propanesulfonic scaffold of TRA.

Compound Structure Indication
1. Unithiol graphic file with name fchem-09-736509-fx1.jpg Mercury, arsenic, and lead poisoning
2. Aurotioprol graphic file with name fchem-09-736509-fx2.jpg Moderate-severe rheumatoid arthritis and tuberculosis
3. Acamprosate graphic file with name fchem-09-736509-fx3.jpg Abstinence from alcohol
4. Menadione graphic file with name fchem-09-736509-fx4.jpg Hypoprothrombinemia
5. Docusate sodium graphic file with name fchem-09-736509-fx5.jpg Occasional constipation
6. Camphotamide graphic file with name fchem-09-736509-fx6.jpg Cardioprotection and neurostimulation
7. Dermatan sulfate graphic file with name fchem-09-736509-fx7.jpg Deep vein thrombosis
8. Ecamsule graphic file with name fchem-09-736509-fx8.jpg Skin protection
9. Sulfamazone graphic file with name fchem-09-736509-fx9.jpg Sulfonamide antibiotic with antipyretic properties
10. Cefpimizole graphic file with name fchem-09-736509-fx10.jpg Infections of skin or soft tissue and urinary tract
11. Glucosulfone graphic file with name fchem-09-736509-fx11.jpg Treatment of malaria tuberculosis and leprosy
12. Solasulfone graphic file with name fchem-09-736509-fx12.jpg Treatment of leprosy
13. Indocyanine green graphic file with name fchem-09-736509-fx13.jpg Ophthalmic angiography and treatment of cancer and acne vulgaris
14. TRA [scaffold] graphic file with name fchem-09-736509-fx14.jpg AD (failed in phase III)