Skip to main content
. Author manuscript; available in PMC: 2022 Nov 4.
Published in final edited form as: Mol Cell. 2021 Oct 6;81(21):4357–4368. doi: 10.1016/j.molcel.2021.09.011

Figure 4. Arginine methylation negatively regulates the anti-viral response.

Figure 4.

A. Methylation of IFI16 (interferon gamma inducible protein 16) and cGAS (Cyclic GMP-AMP synthase) by PRMT5 inhibits the cGAS/STING (Stimulator of Interferon genes) pathway. PRMT5 also negatively regulates the transcription of NLRC5 (NLR family CARD domain containing 5), a crucial transactivator of MHC (major histocompatibility complex) class genes.

B. PRMT7 inhibits RIG-I-like receptors (retinoic acid-inducible gene-I-like receptors, RLRs), MDA5 (melanoma differentiation-associated gene 5), MAVS (mitochondrial antiviral signaling protein) and dsRNA ERV (Endogenous retrovirus) repetitive sequences to inhibit RIG-I signaling. PRMT3 and PRMT6 also inhibit this pathway preventing IRF-3 (Interferon regulatory factor 3) induced type I interferons.