Figure 2.

CerS6 KO male but not female mice gained significantly less weight and fat mass, regardless of dietary folate supplementation. Body mass and composition were measured before and after dietary intervention. Change in body mass was calculated by subtracting pre-diet animal body mass from the post-diet mass. Fat mass was measured by Body Composition Analyzer. Data represent mean ± SEM, n=5. Checkered bars - FD diet; solid bars - Control diet; striped bars - FS diet. WT shown in black and KO shown in grey. *, p<0.05; **, p<0.01; ***, p<0.001; ****, p<0.0001, determined by One-way ANOVA with Sidak’s multiple comparisons test.