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. 2021 Oct 11;20(11):2110–2116. doi: 10.1158/1535-7163.MCT-21-0140

Figure 1.

Figure 1. QBS10072S effectively slows the growth of TNBC. A, Chemical structure of QBS10072S. B, In vitro cytotoxicity of QBS10072S measured in a panel of TNBC cells by MTS assay. Estrogen receptor–positive (ER+) cells are included for comparison. C, Dose-dependent in vitro cytotoxicity of QBS10072S on MDA-MB-231 cells. B and C, Data are mean ± SEM. D, Right, tumor growth inhibition in a subcutaneous xenograft model. MDA-MB-231 cells were implanted in the flanks of nude mice and treatment started after tumors reached the volume of 200 mm3. Mice were treated with 10 mg/kg QBS10072S or vehicle (n = 10 animals/group), given intravenously once a week for 8 weeks. Left, change in body weight of treated animals over the course of the study. Tumors sizes were measured 2–3 × per week. Data are mean ± SD. ****, P < 0.0001; QBS, QBS10072S.

QBS10072S effectively slows the growth of TNBC. A, Chemical structure of QBS10072S. B,In vitro cytotoxicity of QBS10072S measured in a panel of TNBC cells by MTS assay. Estrogen receptor–positive (ER+) cells are included for comparison. C, Dose-dependent in vitro cytotoxicity of QBS10072S on MDA-MB-231 cells. B and C, Data are mean ± SEM. D, Right, tumor growth inhibition in a subcutaneous xenograft model. MDA-MB-231 cells were implanted in the flanks of nude mice and treatment started after tumors reached the volume of 200 mm3. Mice were treated with 10 mg/kg QBS10072S or vehicle (n = 10 animals/group), given intravenously once a week for 8 weeks. Left, change in body weight of treated animals over the course of the study. Tumors sizes were measured 2–3 × per week. Data are mean ± SD. ****, P < 0.0001; QBS, QBS10072S.