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. 2021 Oct 11;20(11):2110–2116. doi: 10.1158/1535-7163.MCT-21-0140

Figure 3.

Figure 3. Breast cancer brain metastases fall into two major categories depending on their association with blood vessels. A, Large bulky metastases contain enlarged blood vessels. B, Top, Representative images showing three types of metastases formed by MDA-MB-231-BR3 cells upon ICA injection: large bulky metastases, small clusters, and single-cell spread. No association was noted between blood vessels and small metastatic clusters or single-cell spread. Bottom, LAT1 expression in all three types of metastases is higher than in the normal brain. BP, brain parenchyma. Arrows point to brain metastases or single cancer cells; scale bars, 200 μmol/L, except for large metastases (first image of each panel), where scale bars, 400 μmol/L.

Breast cancer brain metastases fall into two major categories depending on their association with blood vessels. A, Large bulky metastases contain enlarged blood vessels. B, Top, Representative images showing three types of metastases formed by MDA-MB-231-BR3 cells upon ICA injection: large bulky metastases, small clusters, and single-cell spread. No association was noted between blood vessels and small metastatic clusters or single-cell spread. Bottom, LAT1 expression in all three types of metastases is higher than in the normal brain. BP, brain parenchyma. Arrows point to brain metastases or single cancer cells; scale bars, 200 μmol/L, except for large metastases (first image of each panel), where scale bars, 400 μmol/L.