Figure 4:

A) Gene ontology – biological processes term analysis of differentially expressed genes between male and female cardiac fibroblasts, myeloid, smooth muscle, and valvular interstitial cells. Lists of the differentially expressed genes between males and females from all cell types in the heart can be found in Supplemental Table 1. The gene ratio refers to the number of significantly different genes identified between male and female cells that fit within a specific GO term over the total number of significantly different genes identified. Essentially, the gene ratio signifies the enrichment of the GO term within the significantly differentially expressed gene set. B) Comparisons of differentially expressed genes between male and female cells. ECs = endothelial cells, CFs = cardiac fibroblasts, VICs = valvular interstitial cells. Data for ECs and CFs from heartcellatlas.org. Data for VICs from microarray of porcine VICs [174].