. Author manuscript; available in PMC: 2022 Nov 1.

Published in final edited form as: J Heart Lung Transplant. 2021 May 30;40(11):1454–1462. doi: 10.1016/j.healun.2021.05.012

Table 3.

Association of Microbial Isolates and Histopathology With %ddcfDNA

Group		n (%)	%ddcfDNA	p-value	Subgroup comparison	Subgroup p-value
Pathogen Type
Respiratory Virus		20 (10.87)	0.99 (0.20, 1.89)	0.85	Respiratory Virus	0.57
Bacteria		26 (14.13)	0.73 (0.48, 1.27)		Bacterial
Fungus		33 (17.93)	1.08 (0.33, 2.30)		Fungus
None		105 (57.07)	0.73 (0.33, 1.67)		Fungus
Biopsy and Isolation
Biopsy result	Isolate
Normal	Negative	62 (36.47)	0.74 (0.30, 1.67)	0.13	Normal Biopsy, Isolate Positive	0.05^*
Normal	Positive	55 (32.35)	0.66 (0.21, 1.48)		Normal Biopsy, Isolate Positive
Abnormal	Negative	27 (15.88)	1.03 (0.45, 1.90)		Abnormal Biopsy, Isolate Positive
Abnormal	Positive	26 (15.29)	1.23 (0.42, 2.64)		Abnormal Biopsy, Isolate Positive
Biopsy, Rejection, and Isolation
Abnormal biopsy	Isolate
Non-ACR/AMR	Negative	21 (12.35)	1.03 (0.45, 1.86)	0.98	Non-ACR/AMR Abnormal Biopsy, Isolate Positive	0.76
Non-ACR/AMR	Positive	20 (11.76)	1.13 (0.49, 2.64)		Non-ACR/AMR Abnormal Biopsy, Isolate Positive
ACR/AMR	Negative	6 (3.53)	0.97 (0.62, 4.07)		ACR/AMR, Isolate Positive
ACR/AMR	Positive	8 (4.71)	1.77 (0.30, 3.27)		ACR/AMR, Isolate Positive

Data presented as number (percentage) for categorical variables, and as median (IQR) for continuous variables. Isolate positive, microbial isolate(s) other than normal flora were present in the BAL sample; Isolate negative, microbial isolates(s) other than normal flora not present in BAL; Abnormal biopsy, any abnormal histopathology finding; Non-ACR/AMR Abnormal biopsy, any abnormal histopathology finding other than ACR and without concurrent AMR; ACR/AMR, ACR as a biopsy finding and/or concurrent AMR; Subgroup comparison, categories included in subgroup Kruskal-Wallis or Mann-Whitney U tests.

Statistically significant (p<0.05)