Table 1.
The involvement of LOX-1 in different kinds of cancer.
| Cancer | Tumor database | Blood samples | Histological samples | Cells | Animals | LOX-1 expression levels | LOX-1 role | Ref. |
|---|---|---|---|---|---|---|---|---|
| Colorectal | 238 | 28–100 | DLD-1, HCT-8, RKO | 10 CD-1 nude mice | Overexpression correlates with tumor stage and grade | Prognostic | [29–31] | |
| Breast | 47 | MCF-10A ER-Src and MCF-10A pBABE MCF-12F, MCF-7, MDA-MB231, SKBR-3. | 15 nu/nu nude mice | Overexpression correlates with tumor grade | Predictive | [51–54] | ||
| Prostate | 256 primary prostate tumors | 75 | LNCaP and PC-3 and human C4-2 cell lines | BALB/c mice | High expression in more aggressive and metastatic stage of cancer | Prognostic | [23–28] | |
| Squamous NSCLC | 13 | High expression | Prognostic | [60–62] | ||||
| Lung adenocarcinoma | 19 | HPAEpic, HCC827, A54 9, H441, H446, H460, H5 22 | BALB/C nude mice | High expression | Prognostic | [60, 61] | ||
| Gastric | 100 gastric cancer cases | 80 | MGC80-3 and AGS | Overexpression | Prognostic | [63–67] | ||
| Glioblastoma | 15 | 23 | Lox1pmn + | Prognostic | [72, 73] | |||
| Osteosarcoma | 61 | U2-OS, SAOS-2, 143b and MG63 | 8 BALB/C nude mice | Overexpression | Prognostic | [74, 75] |