Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Nov 5;53(11):1543–1552. doi: 10.1038/s41588-021-00950-8

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 3 — Correlations of genetic risk (coheritability estimates, left) and phenotype (ORs, middle, and liability-scale correlation, right) between IBS and other traits. The subset of all LD Hub traits (excluding rapid GWAS results) with significant genetic correlation (two-tailed coheritability test as implemented in the LDSC with unadjusted P < 0.05) in both UKB data (light blue, 40,548 cases and 293,220 controls) and the independent Bellygenes cohort (orange, 12,852 cases and 139,981 controls) is shown, as well as the meta-analysis used for discovery (black, 53,400 cases and 433,201 controls). IBS had a similar genetic risk profile to traits such as neuroticism, depression and insomnia (for which P values were significant in all datasets after multiple testing correction for the number of traits tested). Traits highlighted in yellow were added manually given their clinical relevance. Anxiety was not initially included since it is only available in the LD Hub as a rapid GWAS result. Among UKB participants, we present ORs (middle) and phenotypic correlations values (right) for these traits. Sample sizes (restricted to UKB participants who were either cases or controls in the discovery cohort; n = 333,768) were as follows: anxiety or panic attacks, 8,714; neuroticism, 271,423 (scores); depressive symptoms, 24,311; insomnia, 326; schizophrenia, 574; bipolar disorder, 1,207; asthma, 41,178.