Table 1.
Demographics, symptom severity, family history and associated conditions for IBS patients diagnosed via different modalities and with different IBS subtypes
| Scores among DHQ participants completing the relevant sections | Among DHQ participants (%) | Atopy (%) | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Group | n | Male (%) | Female (%) | Age (years) | Age (s.d.) | Mean IBS-SSS | Mean PHQ-12 | Mean GAD-7 | Family history of IBS | Childhood antibiotic exposure | Born by Cesarean section | Treatment for anxiety offered or sought | Treatment for depression offered or sought | Pooled asthma/hay fever/eczema |
| Controls (DHQ respondents) | 72,356 | 50.3 | 49.7 | 65.3 | 7.5 | 33 | 4.0 | 1.5 | 9.5 | 9.6 | 2.5 | 16.1 | 18.0 | 18.1 |
| Hospital ICD-10 | 4,237 | 23.4 | 76.6 | 65.9 | 7.9 | 202* | 7.4* | 3.6* | 31.8* | 24.0* | 2.5 | 43.0* | 43.6* | 29.3* |
| Unprompted self-report | 9,309 | 25.7 | 74.3 | 65.2 | 8.0 | 196* | 7.1* | 3.3* | 30.7* | 19.8* | 2.3 | 41.1* | 40.0* | 29.6* |
| DHQ, Rome III criteria | 24,845 | 27.9 | 72.1 | 63.9 | 7.7 | 194* | 7.1* | 3.3* | 24.3* | 20.4* | 2.6 | 33.7* | 35.1* | 24.0* |
| DHQ, self-report | 16,289 | 26.2 | 73.8 | 64.0 | 7.7 | 177* | 6.9* | 3.1* | 29.0* | 21.6* | 2.7 | 39.7* | 39.3* | 25.9* |
| Pooled (any of the four definitions above) | 40,548 | 27.9 | 72.1 | 64.3 | 7.8 | 173* | 6.8* | 3.1* | 24.0* | 20.0* | 2.6 | 34.3* | 35.2* | 24.8* |
| DHQ, Rome III criteria, type C | 3,989 | 16.9 | 83.1 | 64.5 | 7.8 | 190* | 6.8* | 3.2* | 22.2* | 19.2* | 2.2 | 32.3* | 34.1* | 21.4* |
| DHQ, Rome III criteria, type D | 6,506 | 33.2 | 66.8 | 63.8 | 7.7 | 185* | 6.5* | 3.0* | 23.8* | 19.1* | 2.8 | 32.1* | 33.0* | 24.0* |
| DHQ, Rome III criteria, type M | 13,666 | 28.5 | 71.5 | 63.8 | 7.8 | 204* | 7.5* | 3.6* | 25.6* | 21.5* | 2.6 | 35.2* | 36.9* | 24.8* |
| DHQ, Rome III criteria, type U | 672 | 31.0 | 69.0 | 65.6 | 7.5 | 124* | 5.6* | 2.4* | 16.7* | 17.7* | 2.8 | 27.5* | 24.9* | 23.8* |
| DHQ, postinfectious | 860 | 24.2 | 75.8 | 62.2 | 7.8 | 196* | 7.4* | 3.6* | 30.3* | 27.7* | 3.5 | 42.0* | 42.4* | 26.6* |
| DHQ, functional constipation | 3,502 | 33.9 | 66.1 | 67.1 | 7.4 | 64* | 4.7* | 1.8* | 12.5* | 11.0 | 2.5 | 23.1* | 25.4* | 19.0 |
| DHQ, functional diarrhea | 5,386 | 61.0 | 39.0 | 65.1 | 7.5 | 49* | 4.3* | 1.8* | 11.0* | 10.7* | 2.6 | 20.3* | 22.0* | 20.5* |
Digestively healthy controls and functional constipation as well as diarrhea groups are shown for reference. Gastrointestinal symptoms are captured by the IBS-SSS (range 0–500), while somatic symptoms are captured by the (modified) PHQ-12 (range 0–22). The GAD-7 score captures symptoms of anxiety (range 0–21). The single asterisk marks significant differences from the control group after adjusting for age, sex, DHQ participation and (Bonferroni) multiple testing at P < 0.05/108 (two-sided logistic regression test). Age and sex differences were not tested.