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. Author manuscript; available in PMC: 2022 Jun 17.
Published in final edited form as: Pediatr Res. 2021 May 6;91(6):1391–1398. doi: 10.1038/s41390-021-01540-4

Figure 5:

Figure 5:

Effect of mechanical stretch on [Ca2+]i responses in human fetal airway smooth muscle (fASM) cells. fASM cells were exposed to 48h of static 5% stretch mimicking CPAP, on a background of 5% oscillation mimicking breathing. Such stretch enhanced subsequent baseline (A, B) and histamine induced [Ca2+]i responses (A, C). CaSR inhibition with NPS2143 blunted CPAP effects. * indicates significant difference (p<0.05; t-test) between Ctrl and stretch, # indicates significant NPS effect (p<0.05; t-test). N=4–5 cell lines with data averaged from at least 20 cells per line.