Table 2. University of Minnesota Cohort – Demographics.
Demographic characteristics of the University of Minnesota CF Center cohort (Validation Cohort).
| Age | CF Stable (11) | AE (24) |
|---|---|---|
| Age (Mean) | 27.1 | 30.0 |
| Age (STD) | 7.7 | 10.5 |
| Age (Range) | 14–40 | 13–57 |
| Sex | ||
| Female (n) | 7 | 12 |
| Female (%) | 63.6 | 50 |
| Male (n) | 4 | 12 |
| Male (%) | 36.4 | 50 |
| Mutation Background | ||
| F508del/F508del (n) | 6 | 14 |
| F508del/F508del (%) | 54.5 | 58.3 |
| F508del/other (n) | 5 | 9 |
| F508del/other (%) | 45.5 | 37.5 |
| Other mutations (n) | 1 | 0 |
| Other mutations (%) | 9.1 | 0 |
| FEV1 (L) | ||
| FEV1 (Mean) | 2.4 | 1.7 |
| FEV1 (STD) | 0.6 | 0.6 |
| FEV1 (Range) | 1.39–3.85 | 0.70–2.80 |
| FEV1 (%) | ||
| FEV1 (Mean) | 67.3 | 45.3 |
| FEV1 (STD) | 12.1 | 14.1 |
| FEV1 (Range) | 45.5–86.5 | 26–74 |
| BMI | ||
| BMI (Mean) | 21.8 | 21.3 |
| BMI (STD) | 2.1 | 3.1 |
| BMI (Range) | 18.1–24.6 | 13.1–25.8 |
| Exacerbations per year (AE/y) | ||
| AE/y (Mean) | 4.1 | 4.3 |
| AE/y (Range) | 1–12 | 1–10 |
| CF Comorbidities | ||
| PI (n) | 11 | 23 |
| PI (%) | 100 | 95.8 |
| CFRD (n) | 6 | 9 |
| CFRD (%) | 54.5 | 37.5 |
| Microbiology | ||
| PA Colonization (n) | 5 | 9 |
| PA Colonization (%) | 45.5 | 37.5 |
| CFTR Modulators | ||
| Ivacaftor (n) | 0 | 0 |
| Ivacaftor (%) | 0 | 0 |
| Ivacaftor/Lumacaftor (n) | 0 | 0 |
| Ivacaftor/Lumacaftor (%) | 0 | 0 |
CF Stable: CF participants without exacerbation; AE: Participants with active exacerbation.