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. 2021 Aug 5;70(12):3679–3692. doi: 10.1007/s00262-021-03024-0

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — Progression-free survival (a) and Overall survival according to the level or dynamics of different T cell subsets. a Progression-free survival according to the circulating absolute number of CD4 + Treg at baseline; b Overall survival according to a 180 days versus baseline Δ of circulating CD3 + T cell number/μl ≤ (blue line) or > (red line) 37.2; c Overall survival according to a 180 days versus baseline Δ of circulating CD8 + T cell frequency ≤ (blue line) or > (red line) − 0.4; d Overall survival according to a 180 days versus baseline Δ of circulating CD8 + Treg number/μl decreased (blue line) or not-decreased (red line); e Overall survival according to a 180 days versus baseline Δ of circulating CD8 + non-Treg number/μl decreased (blue line) or not-decreased (red line)