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. 2021 Nov 5;12(11):1048. doi: 10.1038/s41419-021-04344-w

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — A Wound healing assay was performed to examine the migration of ESCC cells (KYSE30 and KYSE150) incubated with 100 nM SNS-032. Scale bar: 100 μm. *P < 0.05, **P < 0.01, ***P < 0.001, by Student’s t test. B, C SNS-032 suppressed the migration (B) and invasion (C) of ESCC cells detected by transwell assays. Left: Representative images; Right: Quantitative analysis of five independent experiments. Scale bar: 100 μm. ***P < 0.001, by Student’s t test. D Western blot analysis of MMP-1 and MMP-2 in KYSE30 and KYSE150 cells treated with increasing concentrations of SNS-032 for 48 h. E SNS-032 dose-dependently decreased mRNA levels of MMP-1 in ESCC cells. *P < 0.05; **P < 0.01; ***P < 0.001, one-way ANOVA, post hoc intergroup comparisons, Tukey’s test. F Enforced overexpression of MMP-1 rescued the inhibition of migration and invasion by SNS-032 in KYSE30 cells. *P < 0.05; **P < 0.01; ***P < 0.001, one-way ANOVA, post hoc intergroup comparisons, Tukey’s test. G Silencing MMP-1 by lentiviral shRNA significantly enhanced the inhibitory effects of SNS-032 on the migration and invasion of KYSE30 cells. **P < 0.01; ***P < 0.001, one-way ANOVA, post hoc intergroup comparisons, Tukey’s test.