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. 2021 Nov 5;11:21725. doi: 10.1038/s41598-021-01217-2

Figure 4.

Figure 4

CXCL10 secretion and preventive effect of diosmectite. (a) Levels of CXCL10 measured by ELISA in supernatants of Caco-2 cell cultures treated for 24 h with different concentrations of spike protein RBD (Spike) and heat-inactivated SARS-CoV-2 (CoV-2) as indicated. (b) Levels of CXCL10 measured by ELISA in supernatants of Caco-2 cell cultures treated for 24 h with spike protein RBD (100 ng/mL) and heat-inactivated SARS-CoV-2 (100 ng/mL) alone and after pretreatment with diosmectite (DS). Bars indicate the means and lines the standard deviations of three independent experiments. Student’s t‑test. *p ≤ 0.05. ELISA enzyme-linked immunosorbent assay, DS diosmectite, NT not treated, SARS-CoV-2 severe acute respiratory syndrome coronavirus 2.