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. 2021 Nov 5;11:21738. doi: 10.1038/s41598-021-01101-z

Table 1.

Baseline characteristics of subjects according to thyroid dysfunction.

Variable Total Overt hypothyroidism Subclinical hypothyroidism Euthyroid Subclinical hyperthyroidism Overt hyperthyroidism p-value
2013–2015
Number (%) 5727 30 (0.66) 155 (2.84) 5382 (92.32) 137 (2.64) 23 (0.34)
Age 37.99 ± 0.23 48.72 ± 2.12 39.70 ± 1.62 37.76 ± 0.24 41.87 ± 1.52 35.31 ± 3.46 < 0.001
Sex (female) 2845 (47.93) 22 (76.66) 101 (65.11) 2639 (47.07) 69 (49.23) 14 (69.97) < 0.001
Height 165.00 ± 0.13 160.57 ± 1.50 162.05 ± 0.77 165.17 ± 0.14 163.84 ± 0.78 159.89 ± 2.54 < 0.001
Weight 63.82 ± 0.18 63.42 ± 2.16 61.94 ± 1.02 63.92 ± 0.19 63.31 ± 1.14 56.85 ± 2.91 0.05
Waist circumference 79.15 ± 0.18 82.54 ± 1.69 78.96 ± 0.90 79.15 ± 0.18 79.13 ± 0.84 74.42 ± 2.52 0.11
BMI 23.30 ± 0.06 24.55 ± 0.68 23.49 ± 0.29 23.29 ± 0.06 23.43 ± 0.30 22.14 ± 0.86 0.21
Past history of hypertension 488 (9.07) 2 (7.28) 16 (12.01) 455 (8.96) 13 (10.61) 2 (4.27) 0.69
Current medication on hypertension 378 (7.15) 1 (4.43) 13 (9.57) 349 (7.01) 13 (10.61) 2 (4.27) 0.45
Systolic blood pressure 114.23 ± 0.25 116.63 ± 3.62 114.90 ± 1.36 114.15 ± 0.26 115.20 ± 1.53 118.09 ± 4.25 0.76
Fasting glucose 94.51 ± 0.22 97.78 ± 2.79 93.09 ± 0.87 94.52 ± 0.22 94.60 ± 0.96 95.82 ± 3.06 0.40
Triglyceride 114.48 ± 1.05 159.44 ± 18.15 119.32 ± 6.60 114.23 ± 1.06 111.51 ± 6.17 78.83 ± 6.22 < 0.001
TyG index 4.56 ± 0.00 4.75 ± 0.06 4.58 ± 0.03 4.56 ± 0.00 4.55 ± 0.03 4.41 ± 0.04 < 0.001
TPO positivity 316 (5.47) 16 (56.44) 35 (23.77) 246 (4.37) 13 (8.63) 6 (29.76) < 0.001
2015
Number 1881 19 48 1758 50 6
Fasting glucose 94.75 ± 0.38 96.60 ± 3.90 90.89 ± 1.41 94.83 ± 0.39 94.99 ± 1.40 96.49 ± 6.78 0.09
Triglyceride 115.27 ± 1.75 170.86 ± 24.65 116.77 ± 13.26 114.74 ± 1.71 112.63 ± 11.00 70.12 ± 8.84 < 0.001
HOMA-IR 2.12 ± 0.05 2.40 ± 0.36 2.10 ± 0.24 2.12 ± 0.06 2.11 ± 0.46 2.77 ± 1.00 0.91

BMI body mass index, TyG index triglyceride glucose index, TPO thyroid peroxidase antibody, HOMA_IR homeostasis model assessment of insulin resistance.