. 2021 Nov 5;11:21738. doi: 10.1038/s41598-021-01101-z

Table 5.

Association between categorical thyroid function and HOMA-IR index.

Model^#	Variable	Total (n = 1881)				Male (n = 949)				Female (n = 932)
Model^#	Variable	Beta	95% CI		P value	Beta	95% CI		P value	Beta	95% CI		P value
1					0.365				< 0.0001*				0.348
	Overt hypothyroidism	0.210	− 0.101	0.521	0.184	0.293	− 0.369	0.955	0.386	0.234	− 0.113	0.580	0.186
	Subclinical hypothyroidism	0.027	− 0.160	0.214	0.776	− 0.128	− 0.383	0.127	0.326	0.176	− 0.109	0.461	0.226
	Euthyroid	0 (ref)				0 (ref)				0 (ref)
	Subclinical hyperthyroidism	− 0.147	− 0.368	0.075	0.194	− 0.158	− 0.423	0.107	0.243	− 0.148	− 0.510	0.214	0.422
	Overt hyperthyroidism	0.245	− 0.315	0.805	0.391	0.846	0.794	0.897	< 0.0001	0.218	− 0.368	0.804	0.466
2					0.240				< 0.0001*				0.234
	Overt hypothyroidism	0.284	0.008	0.560	0.044	0.496	− 0.158	1.150	0.137	0.241	− 0.064	0.545	0.121
	Subclinical hypothyroidism	− 0.055	− 0.210	0.101	0.490	− 0.165	− 0.378	0.047	0.127	0.037	− 0.170	0.243	0.728
	Euthyroidism	0 (ref)				0 (ref)				0 (ref)
	Subclinical hyperthyroidism	− 0.048	− 0.221	0.124	0.582	0.006	− 0.210	0.222	0.958	− 0.175	− 0.399	0.050	0.127
	Overt hyperthyroidism	0.254	− 0.317	0.824	0.383	0.304	0.193	0.416	< 0.0001	0.255	− 0.377	0.887	0.429
3					0.139				< 0.0001*				0.211
	Overt hypothyroidism	0.263	0.038	0.488	0.022	0.496	− 0.100	1.092	0.103	0.209	− 0.025	0.444	0.080
	Subclinical hypothyroidism	− 0.044	− 0.194	0.106	0.566	− 0.184	− 0.363	− 0.004	0.045	0.069	− 0.148	0.286	0.533
	Euthyroidism	0 (ref)				0 (ref)				0 (ref)
	Subclinical hyperthyroidism	− 0.032	− 0.202	0.138	0.711	0.020	− 0.189	0.229	0.850	− 0.146	− 0.391	0.099	0.241
	Overt hyperthyroidism	0.306	− 0.235	0.846	0.267	0.255	0.138	0.372	< 0.0001	0.315	− 0.288	0.917	0.306

^#Model 1: linear regression analysis, 2: multiple regression analysis after adjustment for age, sex, systolic blood pressure, BMI, alcohol consumption, 3: multiple regression analysis after adjustment for age, sex, systolic blood pressure, waist circumference, alcohol consumption; HOMA-IR is logarithmic-transformed. *P-values < 0.05 were considered as statistically significant.