Table 1.
Sleep data and serum serotonin levels in OSAS patients before and after CPAP therapy (Me [25; 75])
| Subjects with OSAS (n = 30) | Subjects with OSAS after 3 months of CPAP (n = 30) | p-value (ω) | |
|---|---|---|---|
| AHI (events/h) | 19.8 (16.7–38.0) | 7.2(4.2–10.4) | 0.001 |
| AI (events/h) | 17.4 ( 15.1–24.7) | 2.4 (1.1–4.6) | 0.001 |
| Respiratory arousal index (events/h) | 56.1 (41.3–73.0) | 27.2(27.1–35.8) | 0.003 |
| Average SpO2 values (%) | 86.7 (82.4–90.2) | 91.5(90–95) | 0.003 |
| SpO2 < 90% (% of total sleep time) | 45.7 (42.4–56.8) | 6.2(5.2–12.3) | 0.003 |
| Sleep efficiency (%) | 82.5 (83.1–88.7) | 90.1(91.5–98.4) | 0.001 |
| Stages 1–2 NREM (min) | 256.3 (232.0–276.2) | 180.3(170.0–226.2) | 0.001 |
| Stage 3 NREM (min) | 89.2 (69.1–105.4) | 98.06 (89.06–145.4) | 0.001 |
| REM (min) | 87.0 (62.0–95.0) | 105.8 (102.6–140.1) | 0.001 |
| Serum serotonin (ng/mL) | 20.3 (15.1–26.2) | 26.03 (19.1–30.8) | 0.036 |
ω, Wilcoxon t-test;
OSAS obstructive sleep apnea syndrome, CPAP continuous positive airway pressure, NREM non-rapid eye movement sleep, REM rapid eye movement sleep, AHI apnea hypopnea index, AI apnea index, SpO2 oxygen saturation