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. 2021 Aug 24;10(2):941–953. doi: 10.1007/s40120-021-00272-1

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License, which permits any non-commercial use, sharing, adaptation, distribution, and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc/4.0/.

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Fig. 1 — Incident patient determination. Colors correspond to the labeled stage of disease. Observations that would be included are indicated in the dashed-line boxes. Aβ amyloid-β, AD Alzheimer's disease, MCI-AD mild cognitive impairment due to Alzheimer’s disease