Fig. 1.

Signs and symptoms at enrollment by predominant phenotype. Data cutoff: January 6, 2020. Cardiac phenotype, n = 33; neurologic phenotype, n = 121; mixed phenotype, n = 86. “Autonomic neuropathy” includes dizziness, dry eye, dyshidrosis, palpitations, recurrent urinary tract infections, urinary incontinence, urinary retention, vomiting, constipation, diarrhea, early satiety, fecal incontinence, nausea, erectile dysfunction. “Cardiac disorder” includes coronary artery disease, dyspnea, heart failure, other cardiovascular disease, rhythm disturbance, syncope, myocardial infarction. “Gastrointestinal” includes constipation, diarrhea, early satiety, fecal incontinence, nausea, unintentional weight loss, vomiting. “Motor neuropathy” includes muscle weakness, walking disability. “Other” includes adrenal insufficiency, cerebrovascular accident/stroke, cognitive decline, depression, dialysis, fractures, glaucoma, hyperlipidemia, inflammatory arthritis, inflammatory bowel disease, osteoarthritis, osteoporosis, other endocrine/metabolic disease, other eye disease, other gastrointestinal disease, other genitourinary/reproductive disease, other musculoskeletal disease, other neurologic diagnosis, other psychiatric diagnosis, other respiratory disease, pneumonia, renal impairment, thyroid dysfunction, visual impairment and vitrectomy, transplant, kidney stones, diabetes mellitus, asthma, chronic obstructive pulmonary disease, hepatitis, peptic ulcer disease, chronic demyelinating inflammatory polyneuropathy, carpal tunnel syndrome, seizures, schizophrenia. “Sensory neuropathy” includes balance abnormality, neuropathic arthropathy or pain/paresthesia, numbness, temperature/pain insensitivity, tingling. Categories are not mutually exclusive