Table 4.
Dose-normalized PK parameters for apomorphine by treatment group
| PK parameter | APL (n = 8) | SC-APO (n = 6) | SC-APO-GO (n = 7) |
|---|---|---|---|
| Cmax/dose, ng/ml/mg | 0.28 (57.5) | 2.34 (60.8) | 2.89 (80.9) |
| AUC0–24/dose, h·ng/ml/mg | 0.52 (66.4) | 3.03 (57.9) | 3.28 (61.4) |
| AUClast/dose, h·ng/ml/mg | 0.50 (66.0) | 2.97 (57.5) | 3.23 (62.2) |
| AUC∞/dose, h·ng/ml/mg | 0.52 (66.4) | 3.03 (58.0) | 3.28 (61.4) |
Data are geometric mean (geometric CV%)
Geometric CV% indicates (sqrt [exp (variance for log e transformed data) − 1])·100
APL apomorphine sublingual film, AUC area under the concentration-time curve, AUC0–24 AUC from time 0 to 24 h, AUC∞ AUC from time 0 extrapolated to infinity, AUClast AUC from time 0 to the last measurable plasma concentration, Cmax maximum observed plasma concentration, CV coefficient of variation, PK pharmacokinetics, SC-APO subcutaneous apomorphine injection, SC-APO-GO subcutaneous apomorphine prefilled injection pen